An unofficial workaround until CD PROJEKT RED or Valve fix this properly. As soon as the 5.0 executable sees Wine, it turns off Streamline (DLSS SR/RR, DLSS-G, Reflex), ray tracing, path tracing and FSR frame generation. Everything here brings them back.
Important
The exe patch script supports only bin/x64_dx12/witcher3.exe 5.0.0.1048522 (patch 5.01, 2026-10-08, Steam build 25773555, sha256 2df76539…b101), 5.0.0.1044392 (the 2026-10-01 5.00c hotfix, Steam build 25