Config to run clamAv on macOs with automatic scan once a week. Full configuration for using clamAv antivirus on regular base with automatic scan once a week. It consist of the sh script which perform clamav signatures database update and scanner run, both with appropriate .plist xml files.

avd.sh

#!/usr/bin/env bash
freshclam && clamdscan -i --multiscan --move=/Users/handleman/quarantine ~

com.cisco.clamd.plist

<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE plist PUBLIC "-//Apple Computer//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
<plist version="1.0">
<dict>
    <key>Label</key>
    <string>com.cisco.clamd</string>
    <key>Program</key>
    <string>/usr/local/sbin/clamd</string>
    <key>RunAtLoad</key>
    <true/>
    <key>KeepAlive</key>
    <false/>
</dict>
</plist>

com.cisco.clamdscan.plist

<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE plist PUBLIC "-//Apple Computer//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
<plist version="1.0">
<dict>
    <key>Label</key>
    <string>com.cisco.clamdscan</string>
    <key>Program</key>
    <string>/Users/handleman/projects/scripts/avd.sh</string>
    <key>StartCalendarInterval</key>
    <dict>
        <key>Hour</key>
        <integer>1</integer>
        <key>Minute</key>
        <integer>0</integer>
        <key>Weekday</key>
        <integer>1</integer>
    </dict>
</dict>
</plist>

Creating Launch Agents instruction https://developer.apple.com/library/archive/documentation/MacOSX/Conceptual/BPSystemStartup/Chapters/CreatingLaunchdJobs.html