A killer GNU Screen Config

.screenrc

# the following two lines give a two-line status, with the current window highlighted
hardstatus alwayslastline
hardstatus string '%{= kG}[%{G}%H%? %1`%?%{g}][%= %{= kw}%-w%{+b yk} %n*%t%?(%u)%? %{-}%+w %=%{g}][%{B}%m/%d %{W}%C%A%{g}]'

# huge scrollback buffer
defscrollback 5000

# no welcome message
startup_message off

# 256 colors
attrcolor b ".I"
termcapinfo xterm 'Co#256:AB=\E[48;5;%dm:AF=\E[38;5;%dm'
defbce on

# mouse tracking allows to switch region focus by clicking
mousetrack on

# default windows
screen -t Shell1  1 bash
screen -t Shell2  2 bash
screen -t Python  3 python
screen -t Media   4 bash
select 0
bind c screen 1 # window numbering starts at 1 not 0
bind 0 select 10

# get rid of silly xoff stuff
bind s split

# layouts
layout autosave on
layout new one
select 1
layout new two
select 1
split
resize -v +8
focus down
select 4
focus up
layout new three
select 1
split
resize -v +7
focus down
select 3
split -v
resize -h +10
focus right
select 4
focus up

layout attach one
layout select one

# navigating regions with Ctrl-arrows
bindkey "^[[1;5D" focus left
bindkey "^[[1;5C" focus right
bindkey "^[[1;5A" focus up
bindkey "^[[1;5B" focus down

# switch windows with F3 (prev) and F4 (next)
bindkey "^[OR" prev
bindkey "^[OS" next

# switch layouts with Ctrl+F3 (prev layout) and Ctrl+F4 (next)
bindkey "^[O1;5R" layout prev
bindkey "^[O1;5S" layout next

# F2 puts Screen into resize mode. Resize regions using hjkl keys.
bindkey "^[OQ" eval "command -c rsz" # enter resize mode

# use hjkl keys to resize regions
bind -c rsz h eval "resize -h -5" "command -c rsz"
bind -c rsz j eval "resize -v -5" "command -c rsz"
bind -c rsz k eval "resize -v +5" "command -c rsz"
bind -c rsz l eval "resize -h +5" "command -c rsz"

# quickly switch between regions using tab and arrows
bind -c rsz \t    eval "focus"       "command -c rsz" # Tab
bind -c rsz -k kl eval "focus left"  "command -c rsz" # Left
bind -c rsz -k kr eval "focus right" "command -c rsz" # Right
bind -c rsz -k ku eval "focus up"    "command -c rsz" # Up
bind -c rsz -k kd eval "focus down"  "command -c rsz" # Down

Instead of changing the window numbering to start at 1 I added
bind ` select 0
That key is left of 1 on my keyboard and allows Keyboard position to match the tabs in screen.

@fevisera Tip: it's possible to bind F2 without using terminal-specific sequences, e.g. replace

bindkey "^[OQ" eval "command -c rsz" # enter resize mode

with

bindkey -k k2 eval "command -c rsz" # enter resize mode

because k2 is the termcap name for F2, see man termcap or man terminfo.
Every terminal will set its termcap and screen will use it, no need to hardcode the terminal-specific sequence.

Shift-F2 and Ctrl-F2 are less obvious but do exist in termcap/terminfo:

• Shift-F2 is equivalent to F14 (F2 + 12 function keys), so is F4 in termcap (bindkey -k)
• Ctrl-F2 is equivalent to F26 (F2 + 12 + 12 function keys), so is FG in termcap (bindkey -k)

Ctrl-Shift-F2 is F38 though, I don't know why.