45fix-usb-wakup.sh

#!/bin/bash

# (/usr)/lib/systemd/system-sleep/45fix-usb-wakup
# Disable wakup from USB devices
#
# This is just modification of pm-utils script for systemd sleep hook
# from https://gist.github.com/rutsky/1ed8e9779f0b2941c5a6

[[ "$1" = "pre" ]] || exit 0

function print_state {
    cat /proc/acpi/wakeup | grep $1 | cut -f3 | cut -d' ' -f1 | tr -d '*'
}

function disable_wakup {
    dev=$1
    if [ "`print_state $dev`" == "enabled" ]; then
        echo $dev > /proc/acpi/wakeup
    fi
}

function enable_wakup {
    dev=$1
    if [ "`print_state $dev`" == "disabled" ]; then
        echo $dev > /proc/acpi/wakeup
    fi
}

case $2 in
    suspend)
            echo "Fixing acpi settings."

            # Disable wakup by events from USB hubs
            # (e.g. mouse move on some mices)
            disable_wakup XHC
            ;;
esac

You need to check man systemd-suspend.service for correct path for systemd sleep hook scripts (if /usr/lib/... or only /lib/...)

Doesn't work in 16.04