I'm a little tired, but so far no dice getting it to work properly through WINE. I think once you've authenticated and gotten libraries installed it probably works, but there's a few roadblocks.
To enable OpenGL rendering you'll need to go into drive_c/users/youruser/AppData/Roaming/Dreamtonics/Synthesizer V Studio 2/settings and open settings.xml. I think this file won't generate until you've ran and closed SVS2 at least once.
Under General add the property "useOpenGL" and set it to 1.
<?xml version="1.0" encoding="UTF-8"?>