I'm a little tired, but so far no dice getting it to work properly through WINE. I think once you've authenticated and gotten libraries installed it probably works, but there's a few roadblocks.
To enable OpenGL rendering you'll need to go into drive_c/users/youruser/AppData/Roaming/Dreamtonics/Synthesizer V Studio 2/settings and open settings.xml. I think this file won't generate until you've ran and closed SVS2 at least once.
Under General add the property "useOpenGL" and set it to 1.
<?xml version="1.0" encoding="UTF-8"?>
<ApplicationSettings>
<General useOpenGL="1"/>At this point you'll have a (seemingly) functional UI, but the next hurdle to tackle is to log in.
When you click the log-in button, WINE will by default open the link in your default browser, when you log in it will redirect to a custom uri scheme dreamtonics-svstudio2://and this is where I've gotten stuck.
I found this thread on Reddit where people offer various solutions. I've done the registry editing and had it open a WINE version of Chromium, but no matter what when I log in in the browser and click the uri-scheme, even though Chromium prompts to open SVS2, nothing happens past that and SVS2 just sits there waiting for you to finish logging in.
I've also tried setting a WINE application as a uri handler like described here, but I'm faced with the same problem.
The voice library downloader is a webview, and I've no idea if that will work or not as I've not gotten past the login process.
Lastly, menu items don't really seem to work at all? I can't really explore the application since I'm not authenticated but when you click the menu items they just appear as black for me.